Drug development in lupus has improved over the past 10 years but still lags behind that of other rheumatic disease areas.Assessment of prospective lupus therapies in clinical trials has proved challenging for reasons that are multifactorial including the heterogeneity of the disease, study design limitations and a lack of validated biomarkers whic
Abstract Background Phylogenetic analyses of angiosperm relationships have used only a small percentage of available sequence data, COOKIE DOUGH BAR but phylogenetic data matrices often can be augmented with existing data, especially if one allows missing characters.We explore the effects on phylogenetic analyses of adding 378 matK sequences and 24
A 68-year-old male with a history of hypertension and hypercholesterolemia presented with recurrent episodes of chest discomfort.A 12-lead ECG and an echocardiogram were normal.A myocardial perfusion study could not rule out ischemia in the inferior wall.At coronary angiography using the transradial approach, the right coronary artery (RCA) could n
Nuclear RNA export factors (NXF) are conserved in all metazoans and are deemed essential for shuttling RNA across the nuclear envelope and other post-transcriptional processes (such as mRNA metabolism, storage and stability).Disruption of human NXF5 has been implicated in intellectual and Interface Board psychosocial disabilities.In the present rep
Chromatin regulation is critical for differentiation and disease.However, features linking the chromatin environment of stem cells with disease remain largely unknown.We explored chromatin accessibility in embryonic and multipotent stem cells and unexpectedly identified widespread chromatin accessibility at repetitive elements.Integrating genomic a